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Paul Stamets with an Agarikon fruit body

Mushroom Mycelium Formulas From the Trusted Experts!

Welcome to Host Defense Mushrooms! Founded by Paul Stamets, our mushroom mycelium and fruit bodies grown on our certified organic farm in Washington State are non-GMO, vegan, and gluten-free. We base our formulations on scientifically proven data to ensure quality and safety, which is why we are the best selling mushroom supplement brand in the U.S.ꝉ

A product of Fungi Perfecti, LLC. Building Better Health Since 1980.*

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Host Defense Seals

ꝉ SPINSscan Natural / Natural Products Supermarkets > $2MM / Total US - Natural Channel / Mushrooms Ingredient Report / 52 Wks Ending 12/28/2025

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What People are Saying

  • "These gummies are delicious, and I know that they're full of excellent healthy ingredient. Thank you"

    Shop Grateful Dead Gummies™

    -Madeline G.

  • "The subscribe and save is great, I receive a heads up before shipping. This is a legit company to support."

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    -Eric M.

  • "Taking this has improved my mood and my sleep. I also feel calmer. Thank you."

    Shop Lion's Mane Capsules

    -Sharon B.

  • "Great product. It takes the guesswork out of trying to achieve a balanced blend."

    Shop MyCommunity® Capsules

    -Toni-Jo M.

  • "The product is outstanding it's a lot better than I expected I'm remembering things that I had forgotten a long time ago."

    Shop Lion's Mane Powder

    -Leland M.

  • "Using this primarily for cardiovascular support but there is beneficial calming /centering qualities enjoyed here as well."

    Shop Reishi Extract

    -Michael H.

  • "Cordyceps definitely boosted my energy, in a way that was healthy and not like the boost from caffeine."

    Shop Cordyceps Capsules

    -Sherry B.
Host Defense subscription products

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Why Host Defense

Why Host Defense?

Founded by Paul Stamets
Pioneered by world-renowned mycologist Paul Stamets to connect people with the power of fungi.

Powered by Mushroom Mycelium
The foundation of every Host Defense supplement and our mission.

Innovative Research & Development
Our in-house R&D team drives groundbreaking research in fungi and wellness.

Climate Positive Commitment
We offset 110 percent of our emissions to create a net positive impact for people and planet.

Exceptional Customer Support
Our friendly, knowledgeable team is here to help at every step.

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